Products related to Mendelian:
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Mendelian Randomization : Methods for Causal Inference Using Genetic Variants
Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis.It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics. Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results.The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations.The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language.The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments. FeaturesOffers first-hand, in-depth guidance on Mendelian randomization from leaders in the fieldMakes the diverse aspects of Mendelian randomization understandable to newcomersIllustrates technical details using data from applied analysesDiscusses possible future directions for research involving Mendelian randomizationSoftware code is provided in the relevant chapters and is also available at the supplementary websiteThis book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data. New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues.Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added.The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development
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How we Get Mendel Wrong, and Why it Matters : Challenging the narrative of Mendelian genetics
This book illustrates that the stereotypical representations of Gregor Mendel and his work misrepresent his findings and their historical context.The author sets the historical record straight and provides scientists with a reference guide to the respective scholarship in the early history of genetics.The overarching argument is twofold: on the one hand, that we had better avoid naïve hero-worshipping and understand each historical figure, Mendel in particular, by placing them in the actual sociocultural context in which they lived and worked; on the other hand, that we had better refrain from teaching in schools the naive Mendelian genetics that provided the presumed “scientific” basis for eugenics. Key FeaturesCorrects the distorting stereotypical representations of Mendelian genetics and provides an authentic picture of how science is done, focusing on Gregor Mendel and his actual contributions to scienceExplains how the oversimplifications of Mendelian genetics were exploited by ideologues to provide the presumed “scientific” basis for eugenicsProposes a shift in school education from teaching how the science of genetics is done using model systems to teaching the complexities of development through which heredity is materialized
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Digital Cultural Heritage
This book provides an overview of various application spheres and supports further innovations needed in information management and in the processes of knowledge generation.The professions, organizations and scientific associations involved are unusually challenged by the complexity of the data situation.Cartography has always been the central field of application for georeferencing digital cultural heritage (DCH) objects.It is particularly important in enabling spatial relation analysis between any number of DCH objects or of their granular details.In addition to the pure geometric aspects, the cognitive relations that lead to knowledge representation and derivation of innovative use processes are also of increasing importance.Further, there is a societal demand for spatial reference and analytics (e.g. the extensive use of cognitive concepts of "map" and "atlas" for a variety of social topics in the media).There is a huge geometrical-logical-cognitive potential for complex, multimedia, digital-cultural-heritage databases and stakeholders expect handling, transmission and processing operations with guaranteed long-term availability for all other stakeholders.In the future, whole areas of digital multimedia databases will need to be processed to further our understanding of historical and cultural contexts.This is an important concern for the information society and presents significant challenges for cartography in all these domains. This book collects innovative technical and scientific work on the entire process of object digitization, including detail extraction, archiving and interoperability of multimedia DCH data.
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The Cultural Heritage of Meghalaya
The state of Meghalaya, formed on 21 January 1972, is a state of fascinating socio-cultural significance.Its heritage can be traced from the prehistoric times of Stone Age upto the present.Though comprising mainly of the matrilineal Khasi, Garo, and Jaintia tribes – the state also houses many other lesser known communities such as the Hajong, Sakachep, Biate, Koch, Dalu, Margnar and the Nepali.All these communities find voice in this volume. The Cultural Heritage of Meghalaya looks at the state of Meghalaya exhaustively from the perspective of heritage documentation and maintenance.
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What is Mendelian genetics?
Mendelian genetics is a set of principles established by Gregor Mendel in the 19th century that describes the inheritance of traits from parents to offspring. These principles include the concepts of dominant and recessive alleles, segregation, and independent assortment. Mendelian genetics forms the foundation of modern genetics and helps explain how traits are passed down through generations in a predictable manner.
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Which Mendelian rule fits?
The Mendelian rule that fits is the principle of segregation. This rule states that during the formation of gametes, the two alleles for a gene segregate from each other so that each gamete carries only one allele for each gene. This means that offspring receive one allele from each parent, and the combination of alleles determines the genetic traits of the offspring. This principle helps explain the inheritance patterns of single gene traits in offspring.
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What are the Mendelian inheritance rules?
The Mendelian inheritance rules are a set of principles that describe how genetic traits are passed from parents to offspring. These rules include the principles of dominance, segregation, and independent assortment. Dominance refers to the fact that one allele of a gene may mask the expression of another allele. Segregation describes how alleles separate and are randomly distributed into gametes during meiosis. Independent assortment states that alleles of different genes are inherited independently of each other. These rules form the basis of classical genetics and are fundamental to understanding inheritance patterns in organisms.
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What are the Mendelian laws in genetics?
The Mendelian laws in genetics refer to the principles of inheritance discovered by Gregor Mendel in the 19th century. These laws include the law of segregation, which states that each individual has two alleles for a trait, and these alleles separate during the formation of gametes. The law of independent assortment states that the inheritance of one trait is not dependent on the inheritance of another trait. Finally, the law of dominance states that one allele can be dominant over another, determining the phenotype of the organism. These laws laid the foundation for our understanding of genetic inheritance.
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Analytical Chemistry for Cultural Heritage
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes.The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science.The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole.The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed.The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented.Contributions also offer an outlook on potential future developments in the field.
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Cultural Heritage and Mass Atrocities
A pathbreaking call to halt the intertwined crises of cultural heritage attacks and mass atrocities and mobilize international efforts to protect people and cultures. Intentional destruction of cultural heritage has a long history.Contemporary examples include the Bamiyan Buddhas in Afghanistan, mosques in Xinjiang, mausoleums in Timbuktu, and Greco-Roman remains in Syria.Cultural heritage destruction invariably accompanies assaults on civilians, making heritage attacks impossible to disentangle from the mass atrocities of genocide, war crimes, crimes against humanity, and ethnic cleansing.Both seek to eliminate people and the heritage with which they identify.Cultural Heritage and Mass Atrocities assembles essays by thirty-eight experts from the heritage, social science, humanitarian, legal, and military communities.Focusing on immovable cultural heritage vulnerable to attack, the volume's guiding framework is the Responsibility to Protect (R2P), a United Nations resolution adopted unanimously in 2005 to permit international intervention against crimes of war or genocide.Based on the three pillars of prevent, react, and rebuild, R2P offers today's policymakers a set of existing laws and international norms that can and--as this book argues--must be extended to the protection of cultural heritage.Contributions consider the global value of cultural heritage and document recent attacks on people and sites in China, Guatemala, Iraq, Mali, Sri Lanka and Afghanistan, Syria, and Yemen.Comprehensive sections on vulnerable populations as well as the role of international law and the military offer readers critical insights and point toward research, policy, and action agendas to protect both people and cultural heritage.A concise abstract of each chapter is offered online in Arabic, Chinese, French, Russian, and Spanish to facilitate robust, global dissemination of the strategies and tactics offered in this pathbreaking call to action. The free online edition of this publication is available at getty.edu/publications/cultural-heritage-mass-atrocities.Also available are free PDF, EPUB, and Kindle/MOBI downloads of the book.
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Cultural Heritage and the Future
Cultural Heritage and the Future brings together an international group of scholars and experts to consider the relationship between cultural heritage and the future. Drawing on case studies from around the world, the contributing authors insist that cultural heritage and the future are intimately linked and that the development of futures thinking should be a priority for academics, students and those working in the wider professional heritage sector.Until recently, the future has never attracted substantial research and debate within heritage studies and heritage management, and this book addresses this gap by offering a balance of theoretical and empirical content that will stimulate multidisciplinary debate in the burgeoning field of critical heritage studies. Cultural Heritage and the Future questions the role of heritage in future making and will be of great relevance to academics and students working in the fields of museum and heritage studies, archaeology, anthropology, architecture, conservation studies, sociology, history and geography.Those working in the heritage professions will also find much to interest them within the pages of this book.
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Cultural Disjunctions : Post-Traditional Jewish Identities
The identity of contemporary Jews is multifaceted, no longer necessarily defined by an observance of the Torah and God’s commandments.Indeed, the Jews of modernity are no longer exclusively Jewish.They are affiliated with a host of complementary and sometimes clashing communities—vocational, professional, political, and cultural—whose interests may not coincide with that of the community of their birth and inherited culture.In Cultural Disjunctions, Paul Mendes-Flohr explores the possibility of a spiritually and intellectually engaged cosmopolitan Jewish identity for our time.Reflecting on the need to participate in the spiritual life of Judaism so that it enables multiple relations beyond its borders and allows one to balance Jewish commitment with a genuine obligation to the universal, Mendes-Flohr lays out what this delicate balance can look like for contemporary Jews, both in Israel and in diasporic communities worldwide.Cultural Disjunctions walks us through the labyrinth of twentieth-century Jewish cultural identities and commitments.Ultimately, Mendes-Flohr calls for Jews to remain “discontent,” not just with themselves but also and especially with the reigning social and political order, and to fight for its betterment.
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What does the fourth Mendelian rule state?
The fourth Mendelian rule, also known as the law of independent assortment, states that the inheritance of one trait is independent of the inheritance of another trait. This means that the alleles for different genes are passed on to offspring independently of one another, and the assortment of one pair of alleles does not influence the assortment of another pair of alleles. This rule helps explain the variety of genetic combinations that can occur in offspring, contributing to genetic diversity within a population.
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What does the 5th Mendelian rule state?
The 5th Mendelian rule states that genes located on different chromosomes assort independently during meiosis. This means that the inheritance of one gene does not affect the inheritance of another gene located on a different chromosome. This principle is known as Mendel's Law of Independent Assortment and helps explain the genetic diversity observed in offspring.
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How does the 3rd Mendelian rule work?
The third Mendelian rule, also known as the Law of Independent Assortment, states that different genes for different traits are inherited independently of each other. This means that the inheritance of one gene does not affect the inheritance of another gene. During meiosis, homologous chromosomes randomly assort and separate into different gametes, leading to the independent inheritance of different traits. This rule helps explain the genetic variability seen in offspring and the inheritance patterns of multiple traits.
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Do you need help with Mendelian rules?
Yes, I can help you understand Mendelian rules. Mendelian rules refer to the principles of inheritance discovered by Gregor Mendel, which include concepts such as dominant and recessive alleles, segregation, and independent assortment. I can explain these concepts and help you understand how they apply to genetic inheritance. If you have specific questions or need further clarification on any aspect of Mendelian rules, feel free to ask!
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